diff --git a/README.md b/README.md
index 41287e9a..bce932e3 100644
--- a/README.md
+++ b/README.md
@@ -23,7 +23,7 @@ Then, sync the project dependencies. This will create a virtual environment in `
 uv sync --dev
 ```
 
-> **Note on RDkit:** If you have a different version of rdkit installed globally, the dependency installation may fail. If this happens, please uninstall the global version and run `uv sync` again.
+Note on RDkit installation: if you have rdkit installed on your system globally with a different version of python, the installation will try to link against that and subsequent calls fail. Only option remove global rdkit and rerun sync.
 
 ### 2. Set Up Environment File